Oklo Inc (NYSE:OKLO) stock rose 0.10% (As on March 18, 11:21:11 AM UTC-4, Source: Google Finance) after the company announced the U.S. Department of Energy (DOE) approved its Nuclear Safety Design Agreement (NSDA) for Atomic Alchemy’s Groves Isotopes Test Reactor in Texas under the DOE’s Reactor Pilot Program. Oklo broke ground on its first Aurora powerhouse in September. The company said that it continues to target the deployment of its first powerhouse in 2028. Oklo marked one of the major milestones by receiving its first materials license from the U.S. Nuclear Regulatory Commission (NRC) for its subsidiary, Atomic Alchemy. This approval allows the company to handle, process and distribute isotopes from its Idaho Radiochemistry Laboratory. The license enables the recovery and refinement of materials such as Ra-226, alongside the use of Co-60 and Am-241 for calibration purposes. This development is particularly significant given the growing demand for critical isotopes in medicine, research and industrial applications.

Moreover, Oklo reported a loss of 27 cents per share for the fourth quarter, missing analyst estimates for a loss of 16 cents per share. The pre-revenue company reported operating losses of $139.3 million in 2025. Oklo noted that it expects “significant ongoing operating expenditures” will be necessary to develop powerhouses and fuel fabrication facilities, acquire fuel for powerhouses and expand its radioisotope business. Oklo ended the period with approximately $788.45 million of cash and cash equivalents and $439.53 million of marketable securities. Oklo has a loss from operations of $139.3 million, which was primarily driven by payroll, general business expenses, and professional fees associated with the capital market and asset deployment activities. During the first month of 2026, the company also raised an additional $1.182 billion net of fees, completing the $1.5 billion ATM program.

Oklo said it expects total cash used in operating expenses for 2026 to be in the range of $80 million to $100 million and total cash used in investing activities to be in the range of $350 million to $450 million. For 2026, Oklo has revised its guidance for cash used in operating activities to $80 million-$100 million, up from 2025’s $65 million-$80 million. Fuel development for both the first powerhouse in Idaho, as well as progressing potential fuel projects that could utilize HALEU, plutonium, or recycled transuranic fuel pathways. Isotope project for both Groves in Texas and potential projects in other locations, and other uses to support the overall corporation.